PSVIII-9 Effect of Garlic Extracts on Galectin Protein Secretion in St. Croix Sheep Blood

Abstract The objective of this study was to evaluate the effect garlic extract on modulation Galectin protein secretion in sheep blood. Dietary supplements can influence innate immunity. Garlic (Allium sativum) and its derivatives are eco-friendly non-antibiotic, growth-promoting dietary known modulate inflammation. Galectins (Gals) a family animal lectins that bind β-galactosides. Secreted Gal modulates pathological processes It is important define potential targets for applications health. Clinically, healthy adult, age-matched non-pregnant St Croix (n=12) from NC A&T University farm were divided into treatment group (n=6) control (n=6). Treatment 1 drenched with 5 ml juice (Garlic Barrier (Glendale, CA) concentrate at rate 10 diluted sterile distilled water 1:1. 10ml four weeks. body weight, condition, FAMACHA scores measured weekly. Faecal egg count evaluated using modified McMaster technique. Total plasma analyzed BCA assay. Secretion Gals 1, 3, 9 ELISA kits (My BIOSOURCE). Data T-test where p≤0.05 (SAS9.4 SAS Institute Cary NC). had no significant ©, condition score, packed cell volume, differential white blood count. Fecal decreased significantly treated animals weeks 1(p< 0.034) 3 (p< 0.003). protein, GAL-1 GAL-3 concentration increased 0.004) group. Gal-9 when compared adverse differentially modulated secretion. Further studies required determine health production benefits observed sheep.